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KMID : 0358520080200010046
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Korean Journal of Occupational and Environmental Medicine
2008 Volume.20 No. 1 p.46 ~ p.53
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A Case of Goodpasture’s Syndrome in a Foundry Worker
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Kim Min-Gi
Koh Dong-Hee
Lee Sun-Wung
Jo Min-Heui
Yoo Hee-Yong
Kim Bo-Yeon
Lee June-Hyuk
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Abstract
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Background: Smoking, upper respiratory tract infection, genetic factors and hydrocarbons are known
as risk factors of Goodpasture’s syndrome. We studied a patient with Goodpasture’s syndrome who had
worked for 27 years in a foundry company. Based on a study on the work-relatedness of the syndrome,
we describe and discuss our study results.
Case: A 46-year-old man, who had worked as a foundry worker for 27 years and had a 12 1/2 packyear
history of smoking cigarettes, was admitted into a hospital on 15th February 2006 with coughing,
chest pain and dyspnea. On admission, he had hematuria, proteinuria, severe restrictive pulmonary function
disorder and rapid elevation of blood urea nitrogen/creatinine. Immunological examination showed
ANA (+), ANCA (-) and Anti-GBM Ab (+). Kidney biopsy showed pauci-immune crescentic glomerulonephritis.
Mild bleeding was revealed through bronchoscopy and no vasculitis and granuloma were present on at
lung biopsy. Finally, we diagnosed the worker’s illness as Goodpasture’s syndrome and carried out
hemodialysis and plasmapheresis.
In the workplace survey, the exposure level of respirable crystalline silica exceeded the TLV-TWA
(0.0106 mg/m3), which was calibrated for overtime.
Conclusion: Based on both the clinical test and industrial hygiene examination, we concluded that the
Goodpasture’s syndrome in this case was caused by long-term silica exposure.
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KEYWORD
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Goodpasture’s syndrom, Silica, Foundry worker
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